SYSTEMATIC REVIEW OF COMPATIBILITY OF INTRAVENOUS ACETAMINOPHEN AND KETOPROFEN ADMIXTURE

Abstract

Intravenous administration of acetaminophen and ketoprofen admixture is a common practice among health care providers in hospitals without consideration to their compatibility and stability. Therefore, the aim of this systematic review is to assess the stability and physical and chemical compatibility of intravenous acetaminophen and ketoprofen admixture and to evaluate the quality of the data in these studies. An extensive electronic literature search was conducted on MEDLINE, HINARI, Google scholar database as well as international pharmaceutical peer-reviewed journals to identify original research articles published in the English language from inception to April 2019 on the topic. The quality of the included data was assessed with defined parameters for physical and chemical compatibility. Only five articles fulfilled all inclusion criteria, therefore they were selected and analyzed. Studies imply that acetaminophen and ketoprofen mixtures were stable and compatible physically and chemically, showing neither loss of concentration nor degradation products over 24 to 48 hours.