DESIGN AND EVALUATION OF BUCCAL PATCHES OF LOSARTAN POTASSIUM USING NATURAL GUM

Abstract

In the present study, an attempt was made to develop a novel mucco-adhesive drug delivery system in the form of the buccal patches for the release of Losartan potassium in a unidirectional manner, to maintain constant therapeutic levels of the drug for long time using natural polymer. Buccal formulations containing Losartan potassium mucco adhesive patches were developed to a satisfactory level in term of drug release, bio adhesive strength, content uniformity, moisture content, surface pH, thickness and stability study. The patches were prepared by solvent casting method. Five formulations were developed and formulations with varying concentrations of natural polymers. FTIR studies have shown no indication of interactions between drug and polymer. USP type II apparatus was used to perform in-vitro release study under perfect sink condition. All the formulations followed zero order kinetics. Although all bucco adhesive formulations exhibited satisfactory drug release, best results have been obtained for formulation with higher polymer concentration in terms of evaluations performed. From the results obtained F5 was found as best formulation.