COMPARATIVE EVALUATION OF TAPIOCA SAGO AND POTATO STARCHES AS DISINTEGRATING AGENTS IN TABLET FORMULATION

Abstract

In the present study Tapioca sago starch was employed as a disintegrating agent in Chloroquine based tablets at concentration of 5–15% w/w. Properties of the starch were evaluated for angle of repose, bulk density, tapped density, carr’s compressibility index, hausner’s ratio, hydration capacity and swelling capacity. The granules were evaluated for moisture content, angle of repose, bulk density and tapped density, carr’s compressibility index and hausner’s ratio. The tablets were evaluated for thickness, weight variation, crushing strength, friability, disintegration time and dissolution profiles. Batches of tablets containing equivalent concentration of potato starch were employed as standard. Results obtained indicate that as a disintegrant Tapioca sago starch showed comparable results in Chloroquine phosphate tablets with the standard.