A REVIEW OF FISH MODEL IN EXPERIMENTAL PHARMACOLOGY

Abstract

Recognizing differences in the physiology of fish is essential to understanding the problems associated with drug approval for the aquatic environment. A wide variety of experiments and the use of drugs in fish have been elucidated in various literatures. Antibacterial, antiparasitic and anaesthetic drugs, besides the pharmacokinetic and pharmacodynamic parameters have been well experimented on the fish. Several groups of drugs, such as tetracyclines, penicillins, macrolides, quinolones, sulfonamides, immunostimulants, anticancer agents, herbal drugs and vaccines, have been successfully experimented or used in fish. Hence, fish is also used as a new model organism for different experimental studies of pharmacology and toxicology. The potential for the application of research findings to both human and environmental health issues makes fish species attractive and valuable alternative models in various diseases, including cancer, and pharmacological and toxicological research. Zebrafish has emerged as a major model organism in the developmental genetics, neurophysiology or biomedical research.