FEASIBILITY OF KONDAGOGU GUM AS A CARRIER FOR COLON TARGETED DRUG DELIVERY SYSTEM

Abstract

The present study has been undertaken to develop colon targeted drug delivery system for metoprolol succinate using kondagogu gum as a polymer. Matrix tablets of metoprolol were prepared using PVP K-30 as binder and kondagogu gum as a rate controlling polymer. The prepared tablets were evaluated for properties such as hardness, thickness, friability etc. The prepared tablets were coated with shellac as an enteric coat polymer and evaluated for enteric coat test. In vitro release studies of were carried out for 2 hrs in pH 1.2 HCl buffer, 3 hrs in pH

6.8 phosphate buffer and 7 hrs in the presence of 200 ml of simulated colonic fluid (SCF). In addition, kinetics of drug release from the matrices and stability of the tablet formulations were also investigated. Mathematical analysis of the release kinetics was done using PCP- V02 disso software and it showed that the nature of drug release from the matrix tablets has followed super case II transport which means drug release fro this system is by both diffusion and relaxation of polymer chain. FTIR and DSC studies have shown that no chemical interaction occurred between the drug and polymers used. The optimized formulation (F9) showed negligible difference in release mechanism as well as release kinetics when stability study was done for three months at 40±2⁰ C and 75±5% RH.