SYNTHESIS AND EVALUATION OF NEW 3- SUBSTITUTED-[3, 4- DIHYDROPYRIMIDINONES]-INDOLIN-2-ONES FOR ANALGESIC ACTIVITY

Abstract

45 New 3-substituted [3,4-dihydropyrimidinones]-Indolin-2-ones have been synthesized and tested for Analgesic activity by Eddys Hot plate method on swiss albino mice. Among them compounds AJ₄₃, AJ₄₅, AJ₄₁, AJ₁₆ and AJ₁₇ exhibited higher Analgesic activity. However, the Analgesic activities are lower than standard pentazosin.