DESIGN DEVELOPMENT AND EVALUATION OF TRIMETAZIDINE DIHYDROCHLORIDE FLOATING BILAYER M.R TABLETS

Abstract

Modified release tablet are coated or uncoated tablet containing auxiliary substance or prepared by the procedure that, separately or together are design to modify the rate or place at which the active ingredient are released. Modified release (MR) DDS is an attempt to sustain drug blood concentration at relatively constant and effective level in the body by spatial placement or temporal delivery. Thus controlled release drug delivery system (CRDDS) offer various advantages viz. reduce blood level fluctuations, minimize drug accumulation, employ less total drug, improve patient compliance, and minimize local and systemic side effects.