ENHANCED SOLUBILITY STUDY OF SULPHASALAZINE USING DIFFERENT SOLUBILIZATION TECHNIQUES

Abstract

The aim of present work was to perform a comparative study on effect of solubility of suphasalazine by using different solubilization techniques such as solid dispersion, hydrotropy and micellar solubilization. Hydrotropic studies were carried out using different hydrotropic agents (sodium acetate, sodium benzoate and lignocaine hydrocholride) and Micellar solubilization was carried out using different surfactant solutions (sodium lauryl sulphate, tween 80 and tween 20). Solid dispersion of suphasalazine was prepared by fusion method. PEG (Polyethylene glycol) 4000, mannitol and urea were used as carriers. The solubility enhancement of sulphasalazine by different solubilization technique was observed in decreasing order as hydrotropic solubilization > solid dispersion > micellar solubilization. It was observed that the solubility increased with the increase in the concentration of hydrotropic agents and amongst the various hydrotropic agents used, the solubility of sulphasalazine was enhanced greatest to 40 folds with sodium benzoate. This increase may be attributed due to aggregation of the hydrotropic molecules and inclusion of one of these aggregates at high concentration probably by reacting to form an associated product as a result of hydrogen bonding.