UV-SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN AND NIACIN INDIVIDUALLY AND COMBINED TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION AND ABSORBANCE RATIO METHOD

Abstract

Two UV-spectrophotometric methods were developed and validated for quantitative determination of Rosuvastatin and niacin in combined tablet dosage form

.Method I is based on the simultaneous equation and method II is based on the absorbance ratio method. The absorbance maxima were found to be at 241and 262nm in water for the Rosuvastatin and niacin respectively. Beer’s law is obeyed in the concentration range 5-40µg/ml with correlation coefficient within range of0.998 for both the drugs. The accuracy of the methods was assessed by recovery studies and found to be 98-105%for Rosuvastatin and niacin respectively.