SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDY OF NEW SCHIFF BASE DERIVED FROM AMOXICILLIN DRUG
Keywords:
Acute toxicity., NMR spectroscopy,, Microbial activity,, 2-hydroxy-1- naphthaldehyde,, Amoxicillin,Abstract
Condensation of 4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid,6-[[amino- (4-hydroxy phenyl) acetyl]amino]-3,3-dimethyl-7-oxo,trihydrate with 2- hydroxy-1- naphthaldehyde yielded a novel Schiff base derivative of amoxicillin in good yield. A new compound was characterized by elemental analysis, IR, and 1H-NMR spectroscopy. The synthesized compound was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus, Streptococcus, Klebsella, salmonella and Psedumonas spp and fungicidal activity against Aspergillus multi, Aspergillus niger, Candida albicans, Candida trobicalis and Candida krusi. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon,s up and down method (1980). Studied compound was found to have an LD50 of 492.8 mg / kg of body weight.
