COMPARATIVE STUDY OF OCIMUM SANCTUM OIL AND ANTIMALARIAL TABLETS CONTAINING CHLOROQUINE PHOSPHATE

Abstract

In traditional system of medicine, Ocimum sanctum (known as Tulsi in Hindi), have been recommended for treatment of many diseases such as malaria, diarrhoea, eye diseases, cold disease etc. In this study, the Ocimum sanctum, collected from vidisha region was extracted by steam distillation process. The percentage yield of oil was 0.7 % with specific gravity was 0.92 g/ml. GC-MS analysis of oil showed the percentage of compounds i.e. Eugenol, cyclopentane and caryophyllene and their GC retention times were 5.2 minutes, 5.4 minutes and 6.1 minutes respectively. The chemical equivalence of drugs plays an important role in the quality assurance. In comparative analysis of anti malarial tablets, containing Chloroquine phosphate (CQP), five samples A-E were analysed qualitatively and quantitatively. By experiment and physicochemical test, it was observed that almost all the results are near to the standard values. This brings the need for drug agencies to monitor the quality of the drugs to check adulteration. The result of the study showed that Ocimum sanctum oil has well anti malarial activity with respect to chloroquine phosphate.