DEGRADATION STUDY OF FIVE DIFFERENT BRANDS OF CIPROFLOXACIN USING UV VISIBLE SPECTROPHOTOMETER AND THEIR COMPARATIVE STUDY

Abstract

Degradation studies help to anticipate the future stability issue the drug product may undergo, and provide useful information for both formulation and stability. We explored the degree of degradation in five different brands of Ciprofloxacin tablet, with the purpose to determine the most stable brand out of the five. 500 ppm and 250 ppm samples of each brand were prepared to observe the effect of time, acid (0.1N HCl) and base (0.1N NaOH). Their absorbance was recorded using a Shimadzu UV-Visible spectrophotometer at 271.4 nm. The results suggest that out of the five brands, cyrocin possessed the highest stability and degraded the least.