EVALUATION OF PRESCRIPTION PATTERN AND ASSOCIATED DRUG INTERACTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH COMORBIDITIES AND COMPLICATIONS IN A TEACHING CARE HOSPITAL

Abstract

Type 2 Diabetes Mellitus is a group of metabolic disorders which develops when insulin secretion can no longer compensate for insulin resistance. The effects of diabetes mellitus include organ damage, dysfunction, etc. Physician’s plays a vital role to prescribe anti-diabetic medications and pharmacist plays a keen job to evaluate the prescription pattern in order to optimize a successful therapy. The objectives of our study was to evaluate the prescription pattern of Type 2 Diabetes Mellitus, estimate the occurrence of Diabetes with its comorbidities and complications, monitor the possible drug interactions in the prescription and assess its severity and to assess the occurrence of polypharmacy in Type 2 Diabetes Mellitus patients with comorbidities and complications. A prospective observational study was carried out on type 2 diabetic comorbid and complication patients aged
$\geq$18 years for a period of six months at General Medicine Department of Basaveshwara Medical College Hospital and Research Centre, Chitradurga, Karnataka. A total of 102 patient’s data were collected among which 54 were males and 48 were females. Hypertension was more prevalent in 46-60 age group people. Commonly prescribed antidiabetic drug was Insulin. Diabetes with hypertension comorbidity was more as compared to diabetes with complications. Out of 307 drug interactions 157 were of moderate type followed by 150 minor types of drug interactions. Polypharmacy was assessed and most patients were prescribed with 8-16 drugs per prescription. A successful treatment will come true when a pharmacist maintains good rapport with the physician which would result in safe and effective therapy.