ANTIDIARRHEAL ACTIVITY OF ETANOLIC EXTRACT OF BAY LEAVES (SYZYGIUM POLYANTHUM [WIGHT.] WALP.)

Abstract

Indonesia people have been used of Bay Leaves (S. polyanthum [Wight.] Walp.) to treat of antidiarrhea, cholesterol, hypertension, gastritis, and diabetes mellitus. Extrac of Bay Leaves can be inhibit growth of Escherichia coli, Vibrio Cholera, and Salmonella sp. It’s the bacterium that produce an entherotoxin so as to cause diarrhoea. Bioassay of antidiarrheal activity by using transit intestinal method and mice (Mus musculus) as an animal model induced by castor oil. The mice were grouped into five groups. Group I is received Na-CMC as control, group II, III, and IV are received of Ethanolic Extract of Bay Leaves (EEBL) with concentration 10%, 20%, and 30%, respectively and group V as positive control by received Loperamide-HCl. The charcoal used to marker as indicators. The result of the test indicate that EEBL have antidiarrheal activity to animal model. Refers to analysis of variant p=0.05, showing that concentration 30% has an activity non significant with loperamide-HCl as positive control.