PROTECTIVE EFFECTS OF TINOSPORA CORDIFOLIA AGAINST RESERPINE INDUCED ULCER MODEL

Abstract

We investigated the mechanism underlying the protective effects of Tinospora cordifolia (50 mg/kg and 100 mg/kg) against gastric damage induced by reserpine in adult Sprague Dawley rats. Ulceration was induced in rats by administering 10mg/kg reserpine intraperitoneally (i.p.). The plant was evaluated for its anti-oxidative profile by estimating MDA, GSH, nitrite/nitrate and SOD in rat’s stomach. Pre-treatment with aqueous extract of AETC significantly increased level of endogenous antioxidants (GSH, SOD) and attenuated MDA and nitrite/nitrate levels in the reserpine-treated rats. Thus, it may be concluded that AETC reduced the oxidative stress and consequently improved the integrity of stomach in reserpine-induced ulcers in rats.