GASTRO PROTECTIVE EFFECTS OF FICUS DALHOUSIAE MIQ ROOTS ETHANOLIC EXTRACT IN INDOMETHACIN AND COLD RESTRAINT STRESS INDUCED ULCERS

Abstract

The aim of the present study was to evaluate the gastro protective effects of FDREE in Indomethacin and cold restraint stress induced ulcer models. Wistar albino rats were employed in the study. The preliminary phytochemical screening of the ethanolic extract of root showed the presence of various phytoconstituents namely, tannins, alkaloids flavonoids, glycosides. The acute toxicity of the extract revealed that 2000 mg/kg was safe as no mortality was seen at this dose. Three doses 100, 200 and 400 mg /kg were chosen for the study. The extract elicited significant gastro protective effect in both the ulcer models which was evident by the results of gastric parameters and biochemical assays of Glutathione and Malondialdehyde. The extract significantly lowered the elevated levels of free acidity, total acidity, volume of gastric juice and malondialdehyde when compared with the negative control group. The levels of Glutathione were increased in the test groups. The decrease in gastric volume, total acidity, free acidity and reduction in the levels of Malondialdehyde and increase in the levels of Glutathione in the test groups suggests the gastro protective effect of the plant.