SOLUBILITY ENHANCEMENT OF INDOMETHACIN BY SOLID DISPERSION TECHNIQUE AND DEVELOPMENT OF FAST DISSOLVING TABLETS

Abstract

Solid dispersion had become a potential candidate to overcome the poor solubility of drugs. The aim of the present study was to prepare and compare the dissolution profiles of pure indomethacin and its solid dispersions using PEG4000 and Gelucire 50/13 as carriers and development of FDTs. The solid dispersions were prepared by Melting method. The prepared SDs was subjected to solubility studies in pH 6.8 phosphate buffer. Drug content and dissolution studies of the prepared SDs and PMs were performed and quantification was done by UV/VIS spectrophotometric method at the absorption maximum 320 nm. The prepared SDs was characterized by FT-IR and DSC. Formulation F3 was selected for the Preperation of FDTs because of its maximum solubility, dissolution rates and appearance. Indomethacin FDTs were prepared by direct compression method, using various superdisintegrants croscarmellose, kyron and Indion. Pre-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index and hausner ratio were carried out to study the flow properties of prepared blend to achieve uniformity of tablet weight and the values were within the limits., post-compression studies for the prepared tablets like hardness, weight variation, friability, drug content, wetting time, water absorption ratio, and in vitro disintegration time, in vitro dissolution profiles were performed., results obtained were satisfactory. Formulation T7 containing croscarmellose as superdisintegrant had shown the disintegration within 23 sec and highest release rate of 94.68% at the end of 15 min.