DEVELOPMENT AND EVALUATION OF POORLY AQUEOUS SOLUBLE DRUG RACECADOTRIL BY USING SOLID SELF MICRO EMULSIFYING DRUG DELIVERY APPROACH

Abstract

The objective of present work was to develop solid self-micro emulsifying drug delivery system (SMEDDS) of Racecadotril. Design of SMEDDS formulations helps to improve the oral absorption of highly lipophilic compounds. For formulation of stable SMEDDS, micro emulsion region was identified by constructing Pseudo ternary phase diagram of selected oil surfactant co-surfactant using water titration method. Stable SMEDDS was prepared at ratio of 4:6 using combination of Capryol 90 and Captex 200 (1:1), Cremophore EL and Transcutol (km 2:1) and evaluated for all parameter of liquid SMEDDs. Using aerosil 200, liquid SMEDDS converted into Solid SMEDDS by using adsorption to solid carrier technique. Prepared S-SMEDDS evaluated for micro meretics properties, drug content, dispersibility test, self micro emulsification time, globule size, transparency test, In vitro drug release and in vivo study on male wistar albino rats. From result it showed that drug releases from S- SMEDDS formulations were found to be significantly higher as compared with that of pure drug, and marketed formulation and from in vivo study it was found that S-SMEDDS showed lower frequency, Stool volume and wet diarrheal drops as compared to L-SMEDDS, Plain Drug and marketed formulation. Thus study concluded with S-SMEDDS provides useful solid dosage form to improve solubility and dissolution rate of Racecadotril and concomitantly bioavailability.