EFFECT OF POLYMERS ON DISSOLUTION PROFILE OF VENLAFAXINE HYDROCHLORIDE PELLETS

Abstract

The present invention concerns with the development of modified release capsules of Venlafaxine hydrochloride which are designed to modify the drug release by sustained release action.

The present study was carried out by advanced pelletization technique. Sustained release capsules of Venlafaxine hydrochloride were formulated by using the pelletization process by drug layering on inert sugar pellets by using sucrose and Hypermellose 606 as a binder. The drug layered pellets were coated by using the HPMC, CMC & with Eudragit grades as a coating material, P.E.G-6000 as a plasticizer, aerosil and magnesium stearate as a glidant & Isopropyl alcohol and water used as solvent materials to sustain the drug release.

Formulation of venlafaxine hydrochloride pellets has been done by two stages drug loading and coating. Loading of pellets has been done by coating pan method and the coating has been done by FBC. The coated pellets size and shape is observed during processing.

The coated pellets is filled in capsules size no.2 and these pellets were evaluated for appearance ,angle of repose, compressibility, Hausner’s ratio, Friability test, sieve analysis disintegration and dissolution test were performed & capsules were also evaluated for assay, weight variation, content uniformity, disintegration and in-vitro dissolution tests and observed & they are within range. There is no physicochemical interaction between drug and excipient's.