ACTIVE COMPOUND SUBSTANCE AND ANTICANCER ACTIVITY OF MANGOSTEEN RIND EXTRACT: A REVIEW

Abstract

Recent research on the mangosteen rind was more focused on the content of active substance. This review explored the active substance that had anticancer activity. Review showed that the derivatives of xanthone from mangosteen rind extract containing $\alpha$-mangosteen, $\gamma$-manggosteen, panaxhantone, and garcinon E. Anticancer mechanism of those xanthons derivates were in antiproliferation and apoptosis. $\alpha$-mangosteen was effective for breast-cancer and leukemia, whereas garcinon E was effectively used as an anticancer of liver.