DESIGN AND EVALUATION OF TOPICAL VAGINAL PRONIOSOMAL FORMULATIONS OF TENOFOVIR DISOPROXIL FUMARATE FOR HIV PREVENTION

Abstract

The aim of the present study was to design and evaluate topical proniosomal vaginal gels and proniosomal gel suppositories of Tenofovir Disoproxil Fumarate (TDF) for the treatment of HIV prevention. Evaluation of formulating proniosomal gels was performed such as morphology, pH, entrapment efficiency and In-Vitro diffusion release formulation and also evaluated for EX-Vivo drug permeation and drug retention studies. The optimised ^{formulation F2 from Enriched lecithin (F2) showed a high release rate of 92.2% than F2 (soya lecithin) showed 73%. The %EE had also showed higher for F2 formulation followed by SEM analysis, which showed good vesicles. Ex-vivo studies had been conducted from goat vaginal tissue for 24hrs, F2 gel showed 82.2% release where as 75% found for F2. Proniosomal suppository was prepared from the optimized formulation of proniosomal} gel and characterized the average M.P for Suppositories are found 37.2ºC and average weight of provision suppository found within limits 0.8623. Proniosomal suppository in-vitro dissolution studies showed the controlled release rate when compared to proniosomal formulations. Proniosomal suppository formulation in-order to overcome drug leakage and stability problems of provisional gel TDF.