SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL SCHIFF AND MANNICH BASES DERIVED FROM 1, 2, 4- TRIAZOLES

Abstract

This paper reports the synthesis of a series of 3- substituted 1,2,4-triazole Schiff base (3a-b) and amino methylation reactions were performed with formaldehyde and primary, secondary amine furnished Mannich Schiff base (4a-f),(5a-f).The structure of these compounds were established by IR,¹HNMR,Mass spectral analysis. The synthesized compounds have been screened for antibacterial activity against Escherichia coli, S.aureus, P.aeruginosa, B.subtilis and antifungal activity against A.flavus, T.mentagrophyts. A.fumigatus. P.Marneffei. Among the screened compounds 4a,4c,4d,4f,5a and 5d have shown good antibacterial activity.4c,4d,4f and 5d have shown good antifungal activity. The study shows that the synthesized few compounds are potential lead compounds for future drug discovery studies.