SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF N-DIMETHYLAMINOPHENYLALLYLIDENE CINNAMIDE DERIVATIVES

Abstract

A series of 2 (benzamido) N (3 (4 (dimethylamino)phenyl)allylidene) 3 (substitutedphenyl)acrylohydrazides(3a-m) were synthesized by nucleophilic condensation of various substituted $\alpha$-benzamido cinnamhydrazides(2a-m) with dimethylaminocinnamaldehyde in presence of ethanol and few drops of glacial acetic acid. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR, mass spectral and elemental analysis. Among the compounds evaluated, vanillinyl(3c) and 4-hydroxy-3,4-dimethoxy derivatives(3d) exhibited good antimicrobial activity against all the strains tested, which was comparable to that of standard drugs Ciprofloxacin and Fluconazole and 4 hydroxy 3,4 dimethoxyderivative(3d) showed good antioxidant activity towards all the four models. All the derivatives obey Lipinski rule of five and has good bioactive scores.