ROLES OF MATRIX METALLOPROTEINASES (MMPS) IN CANCER PROGRESSION: A REVIEW

Abstract

Matrix metalloproteinases (MMPs) contain a multigene group of the zinc-dependent extracellular matrix (ECM) renovating endopeptidases involved in pathological processes, for example, carcinogenesis. In such way, their development accepts an important role in tumor improvement and the multistep procedure of invasion and metastasis, including proteolytic degradation of ECM, change of the cell-cell and cell-ECM communications, movement, and angiogenesis. The concealed introduction of the present mini-review is that MMPs can proteolytically process substrates in the extracellular milieu and, in this way, promote tumor progression. In this review it was clear that certain individuals of the MMP family apply revoking roles at different stages amid cancer progression, depending among various factors on the tumor stage, tumor site, enzyme localization, and substrate profile. MMPs are subsequently pleasant to therapeutic intervention by natural inhibitors and synthetic.