CHEMOPREVENTION EFFECT OF CURCUMA AERUGINOSA IN DMBA-INDUCED CYTOKINES PRODUCTION

Abstract

The member of Zingiberaceae, Curcuma aeruginosa Roxb. (C. aeruginosa) has been recognized as medicine for cancer. However, not enough effort has been invested on this herb as chemoprevention agent on cancer development. In this current study, we investigated the influence of C. aeruginosa extracts as a chemo-preventive agent in Wistar rat induced by 7,12-Dimethylbenz[a]anthracene (DMBA). As methods, female Wistar rats were treated with three C. aeruginosa extract doses (CA1: 40mg/ 200g BW; CA2: 80mg/ 200g BW; CA3: 120mg/ 200g BW) in the entire course of the experiment, and were induced with DMBA after one week of administering the extract. As comparison, commercial drugs containing Phyllanthus niruri L. were being used as positive control group, while the group given only DMBA represents the negative control group. Based on experiment, we found that the administration of C. aeruginosa during experiment promotes an increasing in TNF-$\alfa$, IL-2, and IL-12 levels. The dose of 80mg/ 200g BW (CA2) appeared to be best potential dose as chemo-preventive agent represented the smallest tumor incidence and tumor multiplicity at the end of the experiment. Moreover, this plant also efficient to eliminate the cancer cells at the beginning of the tumor until the metastatic phase.