IDENTIFYING DRUG-DRUG INTERACTION AMONG CHRONIC KIDNEY DISEASE PATIENTS IN TERTIARY CARE HOSPITAL

Abstract

Drug-drug interactions (DDIs) are common in clinical practice and are directly related to factors such as polypharmacy, aging, hepatic metabolism and decreased renal function. Individuals with chronic kidney disease (CKD) often require multiple classes of drugs being at important risk for the development of DDIs. The objectives of this study were to identify the drug-drug interactions in CKD patients admitted to medicine ward in KIMS Hospital & Research Centre, and to categorize the drug-drug interactions based on their severity. The prescriptions of 108 patients who fulfilled inclusion criteria of study were analyzed during the study period to determine drug-drug interactions (DDIs). Out of total patient included in the study, in 78 patients medical record, 388 DDIs has been found during patient`s medical record analysis. On correlating between patient`s age group and DDIs it has been found that most number of recorded DDIs, 33 patients (30.56%) were belong to age group between 51-70 years. DDIs has been classified into serious, significant and minor. Out of total 388 DDIs, 57 (14.96%), 220 (56.7%) and 111 (28.61%) were serious, significant and minor DDIs respectively. Among all prescribed drugs, diuretics were among drugs with highest number of DDIs followed by antihypertensive agents, hypoglycemia agents and antithrombotic agents respectively. In relationship between polypharmacy and DDIs the highest number of patients, 48 (44.44%) have been received 13-17 medications. Patients with renal insufficiency are at high risk of drug-drug interactions, especially in the later stages of the disease. Monitoring patient`s medication chart by clinical pharmacist to detect DDIs early can improve quality of patient health care and provide appropriate mechanism for management of drug therapy among CKD patients.