INVESTIGATION OF ANTIEPILEPTIC PROPERTY OF STERCULIA GUTTATA LEAVES

Abstract

The present study was done to investigate the antiepileptic activity of different extracts of leaves of Sterculia guttata. Methanolic and aqueous extracts of the leaves of Sterculia guttata were evaluated for antiepileptic activity using PTZ (Phenyltetrazole 100 mg/kg), MES (Maximal Electroshock Convulsions 75 mA), Strychnine (4 mg/kg) and Picrotoxin (3.5 mg/kg) induced seizures. Swiss albino mice were randomly selected and subjected to dosages of 100, 300 and 500 mg/kg of body weight of each extract used in study. Diazepam and phenytoin were used as standard drugs for all experimental methods in the dose of 4 mg/kg and 25 mg/kg respectively. The results were analyzed by applying one-way ANOVA (Analysis of variance) followed by Dunnett’s t- Test and compared with the control group. The software used for calculating the significance of result was Graph Pad (All values expressed as mean ± SEM; n = 6 mice in each group, significance values are *p < 0.05, **p < 0.01 and ***p < 0.001.) The methanol extracts of leaves of Sterculia guttata showed significant anticonvulsant activity by increasing onset of seizure, the time of latency and reducing duration of extensor phase of seizure in MES and PTZ induced seizures. Picrotoxin and strychnine induced seizure model also showed significant results but up to less extent as compare to MES and PTZ animal models. The ideal dose from the methanol extract was 300 and 500 mg/kg. The aqueous extract showed significant result but only at the dose of 500 mg/kg.