FORMULATION DEVELOPMENT AND EVALUATION OF NANO-STRUCTURED LIPID CARRIERS ENCAPSULATED TOLNAFTATE EMULGEL

Abstract

This research work aimed to “Formulation of tolnaftate (TNF) loaded NLCs emulgel using hot homogenization method followed by ultrasonication method for topical application. The various parameters such as concentration of solid lipid (GMS), liquid lipid (Gelucire 44/14), and the concentration of gelling agent (Carbopol 940) were studied for particle size, zeta potential, %EE, and Viscosity of emulgel. The optimized formulation (F6) was found to be spherical in shape with a mean particle size of 104.8±44.30nm and zeta potential -33.0mV. The maximum % entrapment of tolnaftate in the optimized formulation was found to be 98.23±0.963. The in vitro drug release study demonstrated that the release of the drug from TNF-NLCs emulgel was shown in comparison to marketed formulation (KT5DERM) and pure TNF. Overall, the developed TNF-NLCs emulgel was considered as a potential anti-fungal nano-drug, providing a new direction to the fungal infection treatment.