ULTRAVIOLET-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL AND METFORMIN HYDROCHLORIDE

Abstract

Two simple, precise and economical UV spectrophotometric methods have been developed for the simultaneous estimation of Dapagliflozin and Metformin in bulk drug and marketed formulation. In simultaneous equation method, 223 nm ($\lambda$max of DAPA) and 233 nm ($\lambda$max of MET) analytical wavelengths were selected and analysis were carried out. In area under curve method, 220-229 nm ($\lambda$max of DAPA) and 229-236 nm ($\lambda$max of MET) wavelengths were selected and analysis were carried out. The method was validated using various parameters according to ICH guidelines. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. Assay results were in good agreement with label claim.