SYNTHESIS, ANTIFUNGAL AND ANTI BACTERIAL ACTIVITY OF N-(4-CHLORO-2-TRIFLUOROACTYL PHENYL) - AMINOTHIAZOLE DERIVATIVES

Abstract

In this study,1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone was synthesized by reacting p-chloroaniline with ethyl trifluroacetate in presence of n-butyl lithium, further reacting with ammonium thiocyanate with hydrochloric acid leads to 1-(4-chloro-2-(2,2,2-trifluoroacetyl)phenyl)urea. Then ^{reacted with ArCOCHBr and sodium acetate gave 1-{5-chloro-2[(4-substituted-1, 3-thiazol-2-yl) amino] phenyl}-2,2,2-trifluroethanone derivatives.} The chemical structure of newly synthesized compounds has been confirmed on the basis of elemental analysis, IR, ¹H NMR and Mass spectral data. The newly synthesized compounds were screened for their antibacterial activity invitro against Gram-positive bacteria namely Escherichia coli, Staphylococcus aureus, and Gram-negative bacteria namely Pseudomonas aeruginosa, Bacillus subtilis and the fungus namely Candida albicans by disc diffusion method. Among the synthesized compounds 5b, 5f, 5g, 5h, 5j were found to have a very good antibacterial and antifungal activity.