IMPROVEMENT OF SOLUBILITY OF CINNARIZINE BY USING SOLID DISPERSION TECHNIQUE

Abstract

The aim of present work was to improve the solubility of a poor water soluble drug, cinnarizine, by using solid dispersion technique. Cinnarizine is a H1-receptor antagonist and widely used in the treatment of motion sickness, vomiting and vertigo. In the present work solid dispersion of cinnarizine were prepared with a polyethylene glycol 4000 and polyvinyl pyrrolidone K30 by using solvent evaporation and fusion method in the 1:1, 1:2 and 1:3 ratio of drug and carrier respectively. Solid dispersion of cinnarizine was evaluated for drug content, Infrared spectroscopy and In vitro dissolution study. The solid dispersion with PEG and PVP exhibited enhanced dissolution rate of cinnarizine. IR spectra revealed no chemical incompatibility between drug and carrier. The dissolution of the solid dispersion was carried out in 0.1N HCl. The In vitro dissolution study showed a significant increase in the release rate of cinnarizine in solid dispersion of cinnarizine with polyvinyl pyrrolidone K30 in the ratio 1:3 prepared by solvent evaporation method.