PHARMACOLOGICAL SCREENING OF ANTI-ASTHMATIC ACTIVITY OF ANISOMELES MALABARICA (L).R.BR.EXSIMS

Abstract

Objective: In the study the chloroform and methanolic leaves extract of Anisomeles malabarica Linn (Lamiaceae) was investigated for screening of anti histaminic effect by using guinea pig model. Methods: Identified the protective effect against asthmatic activity using different method like both invivo (Histamine induced bronchospasm in conscious guinea pigs) and invitro(Histamine induced contraction on isolated guinea pig ileum preparation) models. Resuts:. Percentage inhibition of histamine in isolated guinea pig ileum preparation show significant inhibition in standard is 52.26% as like that the extract of MEAM also shows significant inhibition of histamine of about 35.20 %. Conculation:The conculed of the present investigation was find out the anti-asthmatic activity of chloroform and methanolic extract of AM by using histamine induced bronchospsam in conscious guinea pig. The preliminary phytochemical study prove the presence of alkaloids, flavonoids, tri-terpenoids,and saponin. The both extract of CEAM and MEAM was possessing good protection against respiratory disease but methanolic extract 200mg/kg have shows highly protective action than the CEAM.