EFFICIENT SYNTHESIS AND CYTOTOXIC SCREENING OF 3,3 DISUBSTITUTED OXINDOLE DERIVATIVES

Abstract

3,3-disubstituted oxindole derivatives were synthesised by treating isatins with electron rich benzene derivatives at room temperature by using BF3O(Et)2 as catalyst which reduced the synthesis time. The compounds were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds 1(7.2±0.22$\mu$M and 11.80.21±$\mu$M), 2(7.10.24±$\mu$M and 9.8±0.27$\mu$M), exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, respectively.