POTENTIAL USE OF PLANT EXTRACTS OF ALBIZIA SAMAN AS AN ANTI-DIABETIC AGENT

Abstract

Diabetes mellitus is the capital metabolic syndrome of the world. Currently India represents 49% of the world diabetes burden. Diabetic patients encounter considerable morbidity and mortality from various dreadful complications. To have a check over the rising diabetic status, good metabolic control, long lasting changes in lifestyle and pharmacological treatments are required. Chronic use of allopathic drugs results in side effects and an alternate medicine is sought through herbal drugs. Based on the framed objective, the present study focuses on identifying a hypoglycemic agent using plant extract. The aim of the present investigation is to evaluate and identify the active ingredients present and explore the functional groups in 50% hydroethanolic extracts of leaf and bark of A. saman through techniques like GC-MS and FTIR. To substantiate, in vitro inhibitory assay of the plant extracts using alpha- Amylase, alpha-Glucosidase and Glucose diffusion inhibition assays are carried out to confirm the presence of any significant anti-diabetic effect. The results provided a scientific validation of the folklore use of Albizia saman and suggested that this plant (leaf and bark) has promising therapeutic activity for the maintenance of diabetes mellitus.