SCREENING OF BEHAVIOURAL, MUSCLE CO-ORDINATION AND ANXIOLYTIC ACTIVITIES OF METHANOLIC EXTRACT OF HOLOPTELEA INTEGRIFOLIA (ROXB)

Abstract

The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Holoptelea integrifolia (Ulmaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 500 mg/kg. The results of the present study indicates that the methanolic extract of Holoptelea integrifolia leaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.