HPLC METHOD DEVELOPMENT, VALIDATION AND ITS APPLICATION TO STABILITY STUDIES OF CHLORPROMAZINE HYDROCHLORIDE TABLETS

Abstract

Various formulations of chlorpromazine (CPZ) are coming out in the market in combination with different excipients. Although a few high-performance liquid chromatography (HPLC) methods were in action, they were not able to separate in a short time with low cost and easily available mobile phases without affecting the drug components. The main objective of the present study was to develop a new simple HPLC method for identification and quantification of CPZ and its degradation products in tablets and formulations. The advantage of the developed HPLC method was that it was simple isocratic method without using any complicated mobile phase. It was highly sensitive and would be applied to the oxidative degradation studies of CPZ.HCl for monitoring the quality of CPZ.HCl during storage. It could be applicable to different derivatives and metabolites of CPZ and its formulations as well as to other formulations with different new excipients.