FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FLUNARIZINE DIHYDROCHLORIDE BY USING SUPER DISINTEGRANTS

Abstract

Mouth dissolving tablet is the fast growing and highly accepted drug delivery system, Convenience of self administration, compactness and easy manufacturing. This study was aimed at development of Flunarizine dihydrochloride mouth dissolving tablets which can disintegrate or dissolve rapidly once placed in the oral cavity. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease. The tablet was prepared with the three super disintegrants cross carmellose sodium, cross povidone and sodium starch glycolate at different concentrations. The blend was evaluated for angle of repose, bulkdensity, tapped density, compressibility index and hausner’s ratio. The tablets were evaluated for thickness, hardness, friability, weight variation, content uniformity test, wetting time and water absorption ratio, in-vitro dispersion time, dissolution study and FTIR studies. Twelve formulations were for prepared and compare. The optimum formulation was chosen and their predicted results were found to be in close agreement with experimental finding.