FORMULATION AND EVALUATION OF GLICLAZIDE MODIFIED RELEASE TABLETS USING HYDROXYPROPYL CELLULOSE

Abstract

The purpose of this research work was to prepare a modified release tablet of gliclazide by using different grades of Hydroxypropyl cellulose. Infrared spectroscopy study showed that drug and other excipients were compatible with each other. The granules were evaluated for angle of repose, bulk density and compressibility index. The tablets were evaluated to weight variation, thickness, hardness, friability, drug content, in-vitro drug release. The granules showed satisfactory flow properties. All the tablet formulations showed acceptable pharmacotechnical properties and complied in house specifications for tested parameters. The dug release from each preparation was analyzed by using release kinetic theories. This study showed that release process involved erosion and diffusion. The Accelerated stability study was also performed for optimized formulation for three months indicated that optimized formulation was stable.