ENHANCEMENT OF SOLUBILITY FOR CARBAMAZEPINE BY SOLID DISPERSION USING NATURAL GUMS

Abstract

The main objective of the present work is to enhance the dissolution of carbamazepine (BCS class II), poorly soluble drug by solid dispersions using different carriers. Carbamazepine solid dispersions were prepared with different techniques like solvent evaporation, kneading method, physical mixtures by using xanthan gum, modified karaya gum, mannitol and Cochlospermum gossypium gum in different ratios. Resultant formulations were evaluated for solubility studies, FTIR, X-ray diffraction studies, DSC, SEM and in vitro dissolution studies. Solid dispersion prepared by solvent evaporation method with mannitol and xanthan gum as carrier at 1:5 ratio was found to show increased solubility (1.79 ± 0.11) when compared to pure drug (0.017 ± 0.13), physical mixture (0.796 ± 0.23), kneading method (1.42 ± 0.13) and complete release (94.67 ± 1.54) when compared to pure drug

(21.24 ± 0.50), physical mixtures (60.29 ± 1.28) and kneading method (89.677 ± 1.47) in 60 min.