EVALUATION OF ANTI ANXIETY ACTIVITY OF BAMBUSA VULGARIS EXTRACTS IN EXPERIMENTAL ANIMALS

Abstract

The objective of this study is the anxiolytic activity of petroleum ether, chloroform, ethyl acetate and hydroalcoholic extracts of Bambusa vulgaris was investigated by Elevated Plus Maze test, Light and Dark model and Hole Board apparatus. Swiss albino mice were used to evaluate the activity. In each experiment, six animals each were divided into different treatment groups: control group received 10% tween 80, positive control received Diazepam (2 mg/kg) as standard drug and test groups were administered Petroleum ether, Chloroform, Ethyl acetate and Hydroalcoholic extracts of Bambusa vulgaris (200 mg/kg and 400 mg/kg body weight i.p.). The data were subjected to ANOVA followed by tukey’s post- hoc test. In Elevated plus maze model, hydroalcoholic extract (400 mg/kg) of Bambusa vulgaris showed increase in time spent in open arms and number of entries in open arm as compared to control; time spent and number of entries in light area was increased as compared to control in light and dark model; increase in number of head dips as compared to control was observed in Hole Board test. From the observations, it can be concluded that the hydroalcoholic extract of Bambusa vulgaris exhibited significant anxiolytic activity at the dose of 400 mg/kg.