SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

Abstract

The reaction of o-phenylenediamine with anthranillic acid yield compound 2-(1H benzo[d]imidazol-2-yl) aniline (1). The compound (1) was condensed with Chloroacetyl chlorides in the presence of dry benzene to get compound 2-chloro-N-[2-(2,3-dihydro-1Hbenzimidazol-2-yl)phenyl]acetamide.Further it to then treated with KSCN to getan intermediate compound then reacted with corresponding aromatic aldehyde yield compound 5 benzylidene-3-[2-(2,3-dihydro-1H- benzimidazol-2-yl)phenyl]-2-imino-1,3-thiazolidin-4-one. The compounds were synthesizedin good yields and their structures were confirmed by IR, H- NMR-spectral dataand elemental analysis. Antimicrobial activity against bacteria and fungi was studied. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram-positive (S. aureus and B. subtilis), Gram-negative (E. coli, S. typhi) bacteria. Some derivatives showed remarkable activity comparable to that of standard against Gram-positive and Gram-negative bacteria. The results of preliminary biological tests showed that of these compounds possess good biological activities.