ACUTE TOXICITY STUDY OF SIDDHA FORMULATION – GANDHAGA PARPAM

Abstract

The Siddha system of medicine is one of the oldest systems belongs to southern part of India. This system uses a fascinating combination of herbs, minerals, animal products and special therapy techniques like Varmam, Thokkanam therapy to promote health and longevity. Gandhaga parpam is one of the medicines prepared from Sulphur and other ingredients. To study the acute toxicity studies as per WHO guidelines. The Gandhaga parpam was prepared from raw drugs with authentication. The acute toxicity studies carried out in Albino mice (Male and Female) with 10 times of therapeutic dose

i.e. 260 mg/day, water solute, for 2 weeks. Gandhaga parpam at the dose 4.68 mg/animal did not exhibit any mortality in mice. No behavior changes noted for first 4 hours, 24 hours and throughout the study period of 14 days. In addition, no weight reduction happened. Thus, the Siddha formulation of Gandhaga parpam, proves this drug was safe and recommended for human usage. The above result shows that even any metal or mineral medicine should be prepared as per procedure mentioned in classical texts, it does not exhibit any toxicity studies. This will help to reach the Siddha system globally.