SYNTHESIS, CHARACTERISATION, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF ISATIN DERIVATIVES

Abstract

Schiff bases are the important class of organic compounds because of their flexibility and structural diversities due to the presence of azomethine group. In the present study some novel Schiff bases of isatin were synthesized by condensation of isatin molecule with different anilines after performing the molecular docking and ADME prediction. Isatin nucleus contains both the keto and lactam moiety in their structure and has attracted researchers to explore its diverse biological and pharmacological properties. Literature survey has also revealed that isatin derivatives exhibit manifold importance in the field of medicinal chemistry. Therefore, some new Schiff bases of isatin have been prepared in order to study the antimicrobial and antioxidant properties. The isatin was synthesized by Sandmeyer method and then its derivatives were synthesized after obtaining significant results from molecular docking and ADME prediction. The structures of the synthesized compounds were confirmed by means of IR, ¹H-NMR and elemental analysis. These compounds were screened for antimicrobial and antioxidant activity. The compounds showed broad spectrum of antimicrobial activity. Few of the synthesized compounds also showed good antioxidant activity.