ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF DRUG CEFPODOXIME PROXETIL

Abstract

The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Aqueous solubility of any therapeutically active substance is a key property, as it governs dissolution, absorption and thus the in vivo efficacy. The solubility behavior of drug remains one of the most challenging aspects in formulation development. Once if we are able to increase the aqueous solubility of a drug, the disintegration and dissolution properties can be easily altered, as a result, an increase in bioavailability can be easily achieved. This study deals with enhancing the dissolution of poorly soluble Class IV drug Cefpodoxime Proxetil, using different excipients. In order to achieve maximum dissolution, eight different formulations were developed. Optimization has proven as an effective tool in product development. The formulation ARL 8 was found to be optimized product. The different physical properties and in vitro release profile showed better and stable results when compared with marketed product.