FORMULATION AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF GLICLAZIDE BY HYDROTROPY TECHNIQUE

Abstract

The purpose of this research study was to formulate and evaluate fast disintegrating tablet of Gliclazide by hydrotropic solid dispersion technique. The pharmacological response of drug mainly depends on its absorption rate, which in turn depends on drug’s solubility which is an important parameter. Gliclazide is an oral anti hyperglycemic agent useful in lowering the blood glucose level in normal subjects with type 2 diabetics, has poor aqueous solubility. The poor aqueous solubility of medicament results in decreased bioavailability and insufficient therapeutic effect. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug Gliclazide by mixed hydrotropy technique using hydrotropic solutes, such as sodium citrate, sodium salicylate and sodium benzoate. Different ratios of hydrotrops were prepared by solid dispersion technique and optimized was selected for final tablet formulation. To increase the disintegration of the tablet formulation some super disintegrants are used such as crospovidone and sodium starch glycolate. Preparation of tablet by direct compression and evaluation were done. This study revealed the influence of hydrotropic agents in the improvement of solubility of Gliclazide. Compatibility between drug and excipient examined by FTIR and DSC study.