HAEMATINIC ACTIVITY OF ECHURAMOOLI LEAF CHOORANAM IN PHENYLHYDRAZINE INDUCED ANAEMIC RATS

Abstract

Iron deficiency is the most common and widespread nutritional disorder in the world. India is among the countries with highest prevalence of anaemia in the world. It has serious consequences for the health and well-being as well as social and economic impacts of India. Untreated iron deficiency anaemia can become severe enough to interfere with daily life. Knowledge of iron deficiency and its treatment in Siddha System of medicine dates back from time immortal. Many plants in Siddha system of medicine are known to have remarkable effects in treating anaemia. One such medicine is “Echuramooli Leaf Chooranam” Aristolochia indica Linn. The haematinic activity of Echuramooli Leaf Chooranam was studied in Phenylhydrazine induced anaemic rats. Anaemia was induced by an oral administration of Phenylhydrazine for a period of 7 days. The Echuramooli Leaf Chooranam was administered at the various dose levels of 50 mg/kg, 100 mg/kg and 200 mg/kg orally to the animals for 14 days. Hb concentration, RBC count, PCV, MCH, MCHC were analysed as indices of anaemia. Phenylhydrazine significantly decrease the haematological parameters. After 14 days of treatment with trial drug Echuramooli Leaf Chooranam at the dose level of 200 mg significantly reverse the above parameters and turn towards the normal value. This result supports the traditional use of Echuramooli Leaf Chooranam in the treatment of anaemia.