COMPARISON OF VIT D LEVELS AND HBA1C IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Introduction: Diabetes mellitus is a prevalent endocrine disorder associated with numerous complications. Vit D maintains the levels of calcium in the body and it's deficiency leads to inhibition of insulin synthesis seen in diabetes mellitus.
Aim: The aim of the current study was to compare and correlate the levels of Vit D with FBS, PPBS and HbA1c.
Material & Methods: A total of 100 participants divided into Group-I normal patients and Group II patients with diabetes mellitus. Patients >18yrs with type II diabetes mellitus without complications were included and patients with other types of diabetes, on Vit D supplement, bisphosphonate, pregnant women were excluded from the study. 5ml of venous sample was obtained and serum was used to analyze FBS, PPBS, HbA1c, vitamin D were measured and the values were compared and statistically analyzed using unpaired t test and Pearson coefficient correlation. A p value of 0.05 was considered to be statistically significant.
Results: The participants of the study were predominantly females (63) and in the age group of 18-60 years. The values of FBS, PPBS, HbA1c and Vit D were compared among Group I and Group II and were statistically significant. 36 patients of Group II had Vit D deficiency, 9 patients had insufficient Vit D and only 5 patients had sufficient Vit D. Vit D showed an inverse relationship with HbA1c more strongly than other parameters.
Conclusion: An inverse relationship between serum Vit D level and HbA1c, FBS and PPBS. Vit D supplementation in patients with T2DM is associated with improved glycemic control.