RELATIONSHIP BETWEEN ACNE VULGARIS AND HIRSUTISM TO INSULIN RESISTANCE AND TO ASSESS THE SEVERITY OF TWO CONDITIONS WITH INCREASED INSULIN RESISTANCE

Abstract

Background: Acne and hirsutism are common disorders that are simple to cure. They do, however, have a noticeable
effect on how one perceives oneself. There is a lot of research on the pathophysiology of acne and hirsutism, and
insulin resistance is one of them. They are not fully understood, though.
Aim: The purpose of this study was to determine how insulin resistance is related to acne vulgaris and hirsutism, as
well as to evaluate how severe these two disorders are when it comes to insulin resistance.
Methods: A thorough clinical history was taken of each included individual, and then measurements such as height,
weight, and BMI were noted, along with any indications or symptoms of underlying insulin resistance. The global acne
grading system, or GAGS, was used to grade acne, while the modified Ferriman Gallwey score (mFG) was used to
determine the severity of hirsutism. Results were formulated by analysing the data.
Results: Three groups of 174 patients were created, and the group with only acne (154 subjects) showed a strong
association (p<0.0001) between acne severity and insulin resistance with recurrence. With twelve participants, the
hirsutism-only group had a high association between HOMA-IR and mFG score and recurrence, indicating greater
hirsutism severity and increased insulin resistance (p<0.0001 and p<0.007, respectively). Not severity, but BMI and
insulin resistance were positively correlated in the combined hirsutism and acne group.
Conclusion: The current study comes to the conclusion that hirsutism and severe, resistant acne are
pathophysiologically related conditions, with insulin resistance playing a major role. The psychological well-being of
individuals with insulin resistance can be greatly impacted, necessitating the use of an alternative treatment strategy.