ASSESSMENT OF DIFFERENT MORPHOLOGICAL PATTERNS OF CUTANEOUS ADVERSE DRUG REACTION AND THEIR RELATIONSHIP IN INDIAN SUBJECTS

Abstract

Background: Adverse drug reactions, or ADRs, are a typical worry when it comes to medication therapy and one of the
main issues surrounding it. Cutaneous adverse drug responses (CADRs), which varied depending on the medication, are
the most frequent type of adverse drug reaction.
Aim: The purpose of this study was to evaluate the various morphological types of cutaneous adverse medication
reactions in Indian participants and the correlation between them.
Methods: This study evaluated patients where the identification of the medicine could be determined and where
cutaneous adverse drug responses were suspected. The clinical profile and medication history of each participant were
evaluated. The use of the Naranjo scale for the causality evaluation came next.
Results: The most frequent cutaneous adverse drug reaction observed in 49% of research participants was drug eruption
(fixed drug eruption), followed by SJS-TEN spectrum in 17% of respondents and maculopapular rash in 11% of
subjects. A total of 25% (n=36) of the participants experienced severe cutaneous adverse drug reactions (SCARs),
which included DRESS, AGEP, SJS-TEN overlap, and SJS. Antibiotics were the most often reported medication
interaction, with NSAIDs and anticonvulsants following closely behind with 54%, 15%, and 12% of participants,
respectively. The likely group included the bulk of the cutaneous adverse medication responses.
The current investigation reveals that, in comparison to people from other nations, the incidence of severe cutaneous
adverse responses is much greater in Indian subjects.