MICROWAVE ASSISTED SYNTHESIS AND MOLECULAR MODELING STUDIES OF SOME NOVEL POLO-LIKE KINASE 1 INHIBITORS AS ANTICANCER AND ANTI-INFLAMMATORY AGENTS
Keywords:
1, 3 – thiazolidin – 4 – one, Anti-cancer activity, Anti-inflammatory activity, Molecular Modeling, Polo-like kinase 1Abstract
A series of 1, 3-thiazolidin-4-one analogues were synthesized using microwave and structurally characterized by various spectroscopic techniques and elemental analysis. All synthesized compounds were screened for anticancer activity by sulforhodamine B (SRB) assay while in vitro anti-inflammatory activity was by inhibition of albumin denaturation technique. The compounds 5j, 5k, 5l, 5m, 5n were found to show significant anticancer and in vitro anti-inflammatory activity. Furthermore, molecular modelling studies of all molecules (5a-5s) were performed using V Life MDS software. Based on this it is observed that, compound 5m shows more stable complex with Polo-like kinase 1 by forming hydrogen bond and hydrophobic interactions. Finally it is concluded that, 1, 3-thiazolidin-4-one analogues shows anticancer and anti-inflammatory activity possibly because of inhibition of Polo- like kinase 1.
